A VHP Sterilization Pass Box is a specialized cleanroom transfer chamber that combines controlled material transfer with Vaporized Hydrogen Peroxide bio-decontamination.
Unlike an ordinary pass box that mainly separates two areas, or a dynamic pass box that primarily uses filtered airflow to control particles, a VHP pass box introduces a controlled hydrogen peroxide vapor cycle to decontaminate exposed material surfaces before transfer.
This makes it especially suitable for materials that cannot tolerate conventional high-temperature or high-pressure sterilization methods.
The system helps:
Reduce biological contamination during material transfer
Minimize cross-contamination between different cleanroom zones
Protect higher-grade aseptic environments
Decontaminate heat-sensitive materials
Maintain controlled and traceable transfer procedures
Reduce unnecessary personnel movement between cleanroom areas
The system uses vaporized hydrogen peroxide under controlled low-temperature conditions, making it suitable for many materials that are sensitive to high-temperature sterilization.
Typical transfer items include:
Pharmaceutical containers
Rubber stopper bags
API containers
Laboratory instruments
Environmental monitoring equipment
Petri dishes
Sensitive production tools
The internal airflow passes through an H14 high-efficiency filter, helping maintain controlled air cleanliness during the aeration and material transfer process.
This reduces the risk of secondary particle contamination after VHP treatment.
The pass box adopts a double-door structure with interlocking control.
The system prevents both doors from being opened simultaneously, helping maintain separation between adjacent areas.
Available sealing configurations can be customized according to project requirements.
Critical process parameters can be monitored throughout the operating cycle, including:
Temperature
Relative humidity
Chamber pressure
Hydrogen peroxide concentration
Process stage
Cycle status
This allows operators to understand the decontamination process in real time.
The Siemens PLC control system automatically manages each operating stage.
Functions can include:
Automatic cycle control
Parameter setting
Process status display
Alarm management
Cycle monitoring
Data recording
This reduces dependence on manual operation and improves process consistency.
Relevant operating parameters can be recorded during each VHP cycle.
Optional functions can support:
Real-time printing
Cycle records
Historical data
Audit trail
BMS communication
This is particularly valuable for pharmaceutical and other regulated production environments.
The chamber is manufactured from SUS304 stainless steel, providing:
Smooth internal surfaces
Easy cleaning
Good corrosion resistance
Reduced particle accumulation
Long-term durability
The internal structure can be optimized to minimize difficult-to-clean areas.
